The Angeles University Foundation-Institutional Review Board (IRB) was organized in 2003 as part of the PCHRD Twinning Project with the objective of developing and nurturing the research capability of selected Medical Schools in the country to implement and manage research and development activities.

The AUF-IRB started to review research protocols in February 2007 and was registered with the Philippine Health Research Ethics Board (PHREB) on January 09, 2013 as Angeles University Foundation- Angeles University Foundation Medical Center Institutional Ethics Review Committee (AUF-AUFMC IERC).

On April 28, 2015 it changed its name to Angeles University Foundation Institutional Ethics Review Committee (AUF-IERC). The AUF IERC was awarded Level 3 Accreditation by the Philippine National Health Research System (PNHRS) and the PHREB on August 1, 2016.

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